B-hUPAR mice

C57BL/6-Upartm1(UPAR)Bcgen/Bcgen • 111081

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B-hUPAR mice

Catalog Number: 111081
Strain Name: C57BL/6-Upartm1(UPAR)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 5329 (Human)
Aliases: CD87; UPAR; URKR; U-PAR
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B-hUPAR mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      The part of exon 2 and exons 3-7 of mouse Upar gene sequences were replaced by human UPAR counterpart gene sequences in B-hUPAR mice.

      Protein expression analysis
      UPAR (also named PLAUR) expression analysis in homozygous B-hUPAR mice by flow cytometry. Peritoneal macrophages were collected from wild-type mice (+/+) and homozygous B-hUPAR mice (H/H) stimulated with LPS, and analyzed by flow cytometry with species-specific anti-UPAR antibody. Mouse UPAR was detectable in wild-type mice. Human UPAR was detectable in homozygous B-hUPAR mice.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hUPAR mice] (Cat# 111081) was purchased from Biocytogen.