B-Ces1 cluster KO mice

C57BL/6JNifdc-Ces1atm1Bcgen Ces1btm1Bcgen Ces1ctm1Bcgen Ces1dtm1Bcgen Ces1etm1Bcgen Ces1ftm1Bcgen Ces1gtm1Bcgen Ces1htm1Bcgen/Bcgen • 115344

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B-Ces1 cluster KO mice

Catalog Number: 115344
Strain Name: C57BL/6JNifdc-Ces1atm1Bcgen Ces1btm1Bcgen Ces1ctm1Bcgen Ces1dtm1Bcgen Ces1etm1Bcgen Ces1ftm1Bcgen Ces1gtm1Bcgen Ces1htm1Bcgen/Bcgen
Strain Background: C57BL/6JNifdc
Aliases: ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1
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B-Ces1 cluster KO mice

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  • Description
  • Targeting strategy
  • Phenotypic analysis

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    出版物

      Description
      • Ces1 is highly expressed in the liver, macrophages, and small intestine, where it plays key roles in detoxifying ester-containing drugs and xenobiotics, as well as in hydrolyzing cholesteryl esters and triglycerides to regulate lipid and glucose homeostasis.
      • Gene editing strategy: The mouse Ces1a, Ces1b, Ces1c, Ces1d, Ces1e, Ces1f, Ces1g, and Ces1h genes were knock out in B-Ces1 cluster mice.
      • mRNA Expression Analysis: Mouse Ces1 mRNA was exclusively detectable in C57BL/6JNifdc, but not detectable in B-Ces1 cluster KO mice.
      • Application: This product is used for studying prodrug activation, non-alcoholic fatty liver disease, and macrophage lipid metabolism.
      Targeting Strategy

      Gene targeting strategy for B-Ces1 cluster mice. The mouse Ces1a, Ces1b, Ces1c, Ces1d, Ces1e, Ces1f, Ces1g, and Ces1h genes were knock out in B-Ces1 cluster mice.

      mRNA expression analysis

      Strain specific analysis of Ces1 mRNA expression in wild-type C57BL/6JNifdc and B-Ces1 cluster KO mice by RT-PCR. Liver and lung RNA were isolated from wild-type C57BL/6JNifdc (+/+) and homozygous B-Ces1 cluster KO mice (-/-), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mouse Ces1 primers. Mouse Ces1 mRNA was exclusively detectable in C57BL/6JNifdc, but not detectable in B-Ces1 cluster KO mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Ces1 cluster KO mice] (Cat# 115344) was purchased from Biocytogen.