B-hIL17RA mice

C57BL/6-Il17ratm1(IL17RA)Bcgen/Bcgen • 110054

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B-hIL17RA mice

Catalog Number: 110054
Strain Name: C57BL/6-Il17ratm1(IL17RA)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 23765 (Human)
Aliases: CANDF5, CD217, CDw217, IL-17RA, IL17R, IMD51, hIL-17R
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B-hIL17RA mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hIL17RA mice. The exons 2-9 of mouse Il17ra gene that encode the extracellular domain were replaced by human IL17RA exons 2-9 in B-hIL17RA mice.

      Protein expression analysis in granulocytes

      Strain specific IL17RA expression analysis in heterozygous B-hIL17RA mice by flow cytometry. Bone marrow were collected from WT and heterozygous B-hIL17RA (H/+) mice, and analyzed by flow cytometry with species-specific anti-IL17RA antibody. Mouse IL17RA was detectable in WT and heterozygous B-hIL17RA mice. Human IL17RA was exclusively detectable in heterozygous B-hIL17RA but not in WT mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hIL17RA mice] (Cat# 110054) was purchased from Biocytogen.