B-hSTEAP1 MC38

• 322199

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B-hSTEAP1 MC38

Product nameB-hSTEAP1 MC38
Catalog number322199
Strain backgroundC57BL/6
NCBI gene ID26872 (Human)
AliasesPRSS24; STEAP; STEAP1
TissueColon
DiseaseColon carcinoma
SpeciesMouse
ApplicationB-hSTEAP1 MC38 cells have the capability to establish tumors in vivo and can be used for efficacy studies.
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  • Description
  • Targeting strategy
  • Tumorigenicity

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      Description

      The mouse Steap1 gene was replaced by human STEAP1 coding sequence in B-hSTEAP1 MC38 cells. Human STEAP1 is highly expressed on the surface of B-hSTEAP1 MC38 cells.

      Targeting strategy

      Gene targeting strategy for B-hSTEAP1 MC38 cells. The exogenous promoter and human STEAP1 coding sequence was inserted to replace part of murine exon 3. The insertion disrupts the endogenous murine Steap1 gene, resulting in a non-functional transcript.

      Tumor growth curve & Body weight changes
      Subcutaneous homograft tumor growth of B-hSTEAP1 MC38 cells. B-hSTEAP1 MC38 cells (1x107) and wild-type MC38 cells (5x105) were subcutaneously implanted into C57BL/6 mice (female, 11-week-old, n=8). Tumor volume and body weight were measured twice a week. (A) Average tumor volume ± SEM. (B) Body weight (Mean± SEM). Volume was expressed in mm3 using the formula: V=0.5 X long diameter X short diameter2. As shown in panel A, B-hSTEAP1 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.
      Tumor growth curve of individual mice
      B-hSTEAP1 MC38 tumor cells growth of individual mice. B-hSTEAP1 MC38 cells (1x107) and wild-type MC38 cells (5x105) were subcutaneously implanted into C57BL/6 mice (female, 11-week-old, n=8). As shown in panel, B-hSTEAP1 MC38 cells were able to establish tumors in vivo and can be used for efficacy studies.