B-hCD43 mice

C57BL/6N-Spntm1(SPN)Bcgen/Bcgen • 110892

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B-hCD43 mice

Catalog Number: 110892
Strain Name: C57BL/6N-Spntm1(SPN)Bcgen/Bcgen
Strain Background: C57BL/6N
NCBI gene ID: 6693 (Human)
Aliases: LSN; CD43; GALGP; GPL115; LEU-22
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B-hCD43 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCD43 mice. The exon 3 of mouse Cd43 gene that encodes the extracellular domain was replaced by human CD43 exon 3 in B-hCD43 mice.

      mRNA expression analysis

      Strain specific analysis of CD43 gene expression in wild type (WT) and B-hCD43 mice by RT-PCR. Human CD43 mRNA was detectable only in splenocytes of the homozygous B-hCD43(H/H) mice but not in wild type (+/+) mice.

      Protein expression analysis

      Strain specific CD43 expression analysis in WT and homozygous B-hCD43 mice by flow cytometry. Splenocytes were collected from wild type(+/+) and homozygous B-hCD43 (H/H) mice. Mouse CD43 was detectable only in the WT mice. Human CD43 was detectable only in the homozygous B-hCD43(H/H) mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCD43 mice] (Cat# 110892) was purchased from Biocytogen.