B-hIGFBP7 mice

C57BL/6-Igfbp7tm2(IGFBP7)/Bcgen • 111976

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B-hIGFBP7 mice

Catalog Number: 111976
Strain Name: C57BL/6-Igfbp7tm2(IGFBP7)/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 3490 (Human)
Aliases: AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1
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B-hIGFBP7 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hIGFBP7 mice. The exons 1-5 of mouse Igfbp7 gene were replaced by exons 1-5 of human IGFBP7 gene in B-hIGFBP7 mice.

      Protein expression analysis

      Strain specific IGFBP7 expression analysis in homozygous B-hIGFBP7 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hIGFBP7 mice (H/H), and analyzed by ELISA with species-specific IGFBP7 ELISA kit. Mouse IGFBP7 was only detectable in wild-type mice. Human IGFBP7 was exclusively detectable in homozygous B-hIGFBP7 mice but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hIGFBP7 mice] (Cat# 111976) was purchased from Biocytogen.