B-hTIMP1 mice

C57BL/6N-Timp1tm1(TIMP1)Bcgen/Bcgen • 112339

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B-hTIMP1 mice

Catalog Number: 112339
Strain Name: C57BL/6N-Timp1tm1(TIMP1)Bcgen/Bcgen
Strain Background: C57BL/6N
NCBI gene ID: 7076 (Human)
Aliases: EPA; EPO; HCI; CLGI; TIMP; TIMP-1
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B-hTIMP1 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hTIMP1 mice. The exons 2-6 of mouse Timp1 gene that encode the full-length protein, not including signal peptide were replaced by human TIMP1 exons 2-6 in B-hTIMP1 mice.

      Protein expression analysis
      Strain specific TIMP1 protein expression analysis in homozygous B-hTIMP1 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hTIMP1 mice(H/H), and analyzed by ELISA with species-specific TIMP1 ELISA kit. Mouse TIMP1 was detectable in wild-type mice. Human TIMP1 was exclusively detectable in homozygous B-hTIMP1 mice.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hTIMP1 mice] (Cat# 112339) was purchased from Biocytogen.