• 311530
Product name | B-hAMHR2 MC38 |
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Catalog number | 311530 |
Strain background | C57BL/6 |
NCBI gene ID | 269 (Human) |
Aliases | AMHR; MISR2; MISRII; MRII; AMHR2 |
Tissue | Colon |
Disease | Colon carcinoma |
Species | Mouse |
Application | B-hAMHR2 MC38 cells have the capability to establish tumors in vivo and can be used for efficacy studies. |
Gene targeting strategy for B-hAMHR2 MC38 cells. The exogenous promoter and human AMHR2 coding sequence were inserted to replace part of murine exon 2 and all of exon 3. The insertion disrupts the endogenous murine Amhr2 gene, resulting in a non-functional transcript.
Gene targeting strategy for B-hAMHR2 MC38 cells. The exogenous promoter and human AMHR2 coding sequence was inserted to replace part of murine exon 2 and all of exon 3. The insertion disrupts the endogenous murine Amhr2 gene, resulting in a non-functional transcript.
AMHR2 expression analysis in B-hAMHR2 MC38 cells by flow cytometry. Single cell suspensions from wild-type MC38 and B-hAMHR2 MC38 cultures were stained with species-specific anti-AMHR2 antibody. Human AMHR2 was detected on the surface of B-hAMHR2 MC38 cells, but not on the surface of wild-type MC38 cells. The 1-A01 clone of B-hAMHR2 MC38 cells was used for in vivo experiments.