B-NDG hFcRn mice

NOD.CB17-PrkdcscidIl2rgtm1BcgenFcgrttm1(FCGRT)Bcgen/Bcgen • 111922

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B-NDG hFcRn mice

Catalog Number: 111922
Strain Name: NOD.CB17-PrkdcscidIl2rgtm1BcgenFcgrttm1(FCGRT)Bcgen/Bcgen
Strain Background: B-NDG
NCBI gene ID: 2217,3561,5591 (Human)
Aliases: FCRN; FcgammaRn; alpha-chain; P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1; HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; S473K; XRCC7; DNAPKc; DNA-PKC; DNA-PKcs
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B-NDG hFcRn mice

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  • Phenotypic analysis
  • Efficacy

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      Protein expression analysis
      Strain specific analysis of FcRn expression in B-NDG mice and B-NDG hFcRn mice by western blot. Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
      Serum half-life of antibody drug in B-NDG hFcRn mice
      Pharmacokinetics of YERVOY-analog (isotype: human IgG1) in B-NDG hFcRn mice.B-NDG mice and B-NDG hFcRn mice were intravenously injected with YERVOY (in house), the isotype of YERVOY (in house) is human IgG1, and serum was collected for pharmacokinetic (PK) analysis (n=3). A, The PK curve. B, The PK parameters. Data are shown in mean ± SEM.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-NDG hFcRn mice] (Cat# 111922) was purchased from Biocytogen.