B-Grpr-iCre mice

C57BL/6-Grprtm1(icre)Bcgen/Bcgen • 110125

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B-Grpr-iCre mice

Product nameB-Grpr-iCre mice
Catalog number110125
Strain nameC57BL/6-Grprtm1(icre)Bcgen/Bcgen
Strain backgroundC57BL/6
NCBI gene ID14829 (Mouse)
Official symbolGrpr(gastrin releasing peptide receptor), GR; GRP-R
ChromosomeX
AliasesGRP-R
ApplicationFunction research of genes; This GrpriCre model is an efficient tool to study various gene functions when crossed with mice with different loxP site-flanked genes of interest, especially in studies of pruritogenic stimuli, long-term potentiation (LTP) and amygdala-dependent memoryfor fear
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  • Targeting strategy
  • Phenotypic analysis

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      Gene editing strategy
      An F2A-iCre sequence cassette was placed between the coding sequence of exon 3 and 3’UTR of the Grpr gene in C57BL/6 ES cells. This strain was maintained on a C57BL/6 genetic background.
      Phenotype Analysis

      (I) Schematic depicting virus and retrobeads injection, as well as recording configuration in spinal slices. (J) All recorded cells were filled with biocytin (blue) and were beads-positive (red). GRPR+ fibers were labeled with EYFP (green). Scale bar, 10 mm.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Grpr-iCre mice] (Cat# 110125) was purchased from Biocytogen.